expression data for 79 human tissues Search Results


rna gtex database  (Human Protein Atlas)
86
Human Protein Atlas rna gtex database
Rna Gtex Database, supplied by Human Protein Atlas, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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human tissue expression data  (Human Protein Atlas)
86
Human Protein Atlas human tissue expression data
a , Schematic representation of ceramide hydrolysis by membrane-tethered Asah2. Cer, ceramide; Sph, sphingosine. Image was created with BioRender.com. b , Loss of Asah2 activity is associated with a longer lifespan. Protein domain architectures of Asah2 are shown. Blue box, catalytic domain; orange box, immunoglobulin (Ig)-like domain; white box, other regions; grey box, N. furzeri MZM-specific region; red vertical lines in <t>human</t> ASAH2, essential amino acid residues required for enzymatic activity. c, e , asah2 is specifically expressed in the intestine and increases with age. <t>Expression</t> levels of asah2 mRNA in various <t>tissues</t> ( c ) and in the intestine ( e ) of 2- and 4-month-old wild-type (WT) and asah2 knockout (KO) N. furzeri are shown. In c and e , mRNA levels were analysed by reverse transcription quantitative PCR (RT–qPCR) and RNA sequencing (RNA-seq), respectively. CPM, counts per million; FDR, false discovery rate. FDR values were derived from quasi-likelihood methods in edgeR. d , Asah2 protein localises to the apical /luminal side of intestinal epithelium in short-lived GRZ fish but is absent in long-lived MZM fish and asah2 KO fish. Representative images of intestinal sections immunostained with anti-Asah2 antibody (green) and 4′,6-diamidino-2-phenylindole (DAPI; blue) are shown. Scale bar, 200 μm. f , Pooled censoring-aware parental survival analysis showing that higher participant plasma ASAH2 z-score was associated with higher pooled parental hazard, consistent with lower parental longevity. The displayed p-value tests the overall ASAH2-parental hazard association in the stratified cubic B-spline Cox model. Primary statistical inference was based on the cluster-robust linear Cox model. g , CRISPR/Cas9-mediated asah2 knockout. Top, schematic representation of the asah2 locus (black boxes, exons; ATG, start codon) and two sgRNA target sites (orange boxes). Bottom left, DNA sequences of WT and asah2 KO. The red horizontal line denotes the 4 bp deletion. Bottom right, the mutation was predicted to result in loss of the C-terminal domain of the Asah2 protein. Blue, catalytic domain; orange, Ig-like domain; white, other regions; grey, asah2 KO N. furzeri- specific region. h , Expression of Asah2 in the intestine of short-lived N. furzeri analysed by Western blotting. i, j , asah2 KO extends lifespan ( i ) and improves locomotor activity ( j ). In i , survival curves of male WT (blue) and asah2 KO (orange) fish are shown on the left; the corresponding statistical results, mean lifespan and maximum lifespan are shown on the right. Black dots indicate censored individuals. Graphs in j show exploratory behaviour in male WT (blue) and asah2 KO (orange) fish. The y-axis indicates the average velocity. The log-rank test, fixed-time survival test, and unpaired two-tailed t -test were used for i , and a Brown–Forsythe and Welch ANOVA followed by Dunnett’s T3 multiple-comparisons test were used for j . Bars and error bars represent the mean ± SD.
Human Tissue Expression Data, supplied by Human Protein Atlas, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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tissue wide protein expression data  (Human Protein Atlas)
86
Human Protein Atlas tissue wide protein expression data
a , Schematic representation of ceramide hydrolysis by membrane-tethered Asah2. Cer, ceramide; Sph, sphingosine. Image was created with BioRender.com. b , Loss of Asah2 activity is associated with a longer lifespan. Protein domain architectures of Asah2 are shown. Blue box, catalytic domain; orange box, immunoglobulin (Ig)-like domain; white box, other regions; grey box, N. furzeri MZM-specific region; red vertical lines in <t>human</t> ASAH2, essential amino acid residues required for enzymatic activity. c, e , asah2 is specifically expressed in the intestine and increases with age. <t>Expression</t> levels of asah2 mRNA in various <t>tissues</t> ( c ) and in the intestine ( e ) of 2- and 4-month-old wild-type (WT) and asah2 knockout (KO) N. furzeri are shown. In c and e , mRNA levels were analysed by reverse transcription quantitative PCR (RT–qPCR) and RNA sequencing (RNA-seq), respectively. CPM, counts per million; FDR, false discovery rate. FDR values were derived from quasi-likelihood methods in edgeR. d , Asah2 protein localises to the apical /luminal side of intestinal epithelium in short-lived GRZ fish but is absent in long-lived MZM fish and asah2 KO fish. Representative images of intestinal sections immunostained with anti-Asah2 antibody (green) and 4′,6-diamidino-2-phenylindole (DAPI; blue) are shown. Scale bar, 200 μm. f , Pooled censoring-aware parental survival analysis showing that higher participant plasma ASAH2 z-score was associated with higher pooled parental hazard, consistent with lower parental longevity. The displayed p-value tests the overall ASAH2-parental hazard association in the stratified cubic B-spline Cox model. Primary statistical inference was based on the cluster-robust linear Cox model. g , CRISPR/Cas9-mediated asah2 knockout. Top, schematic representation of the asah2 locus (black boxes, exons; ATG, start codon) and two sgRNA target sites (orange boxes). Bottom left, DNA sequences of WT and asah2 KO. The red horizontal line denotes the 4 bp deletion. Bottom right, the mutation was predicted to result in loss of the C-terminal domain of the Asah2 protein. Blue, catalytic domain; orange, Ig-like domain; white, other regions; grey, asah2 KO N. furzeri- specific region. h , Expression of Asah2 in the intestine of short-lived N. furzeri analysed by Western blotting. i, j , asah2 KO extends lifespan ( i ) and improves locomotor activity ( j ). In i , survival curves of male WT (blue) and asah2 KO (orange) fish are shown on the left; the corresponding statistical results, mean lifespan and maximum lifespan are shown on the right. Black dots indicate censored individuals. Graphs in j show exploratory behaviour in male WT (blue) and asah2 KO (orange) fish. The y-axis indicates the average velocity. The log-rank test, fixed-time survival test, and unpaired two-tailed t -test were used for i , and a Brown–Forsythe and Welch ANOVA followed by Dunnett’s T3 multiple-comparisons test were used for j . Bars and error bars represent the mean ± SD.
Tissue Wide Protein Expression Data, supplied by Human Protein Atlas, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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tissue mrna expression data  (Human Protein Atlas)
86
Human Protein Atlas tissue mrna expression data
a , Schematic representation of ceramide hydrolysis by membrane-tethered Asah2. Cer, ceramide; Sph, sphingosine. Image was created with BioRender.com. b , Loss of Asah2 activity is associated with a longer lifespan. Protein domain architectures of Asah2 are shown. Blue box, catalytic domain; orange box, immunoglobulin (Ig)-like domain; white box, other regions; grey box, N. furzeri MZM-specific region; red vertical lines in <t>human</t> ASAH2, essential amino acid residues required for enzymatic activity. c, e , asah2 is specifically expressed in the intestine and increases with age. <t>Expression</t> levels of asah2 mRNA in various <t>tissues</t> ( c ) and in the intestine ( e ) of 2- and 4-month-old wild-type (WT) and asah2 knockout (KO) N. furzeri are shown. In c and e , mRNA levels were analysed by reverse transcription quantitative PCR (RT–qPCR) and RNA sequencing (RNA-seq), respectively. CPM, counts per million; FDR, false discovery rate. FDR values were derived from quasi-likelihood methods in edgeR. d , Asah2 protein localises to the apical /luminal side of intestinal epithelium in short-lived GRZ fish but is absent in long-lived MZM fish and asah2 KO fish. Representative images of intestinal sections immunostained with anti-Asah2 antibody (green) and 4′,6-diamidino-2-phenylindole (DAPI; blue) are shown. Scale bar, 200 μm. f , Pooled censoring-aware parental survival analysis showing that higher participant plasma ASAH2 z-score was associated with higher pooled parental hazard, consistent with lower parental longevity. The displayed p-value tests the overall ASAH2-parental hazard association in the stratified cubic B-spline Cox model. Primary statistical inference was based on the cluster-robust linear Cox model. g , CRISPR/Cas9-mediated asah2 knockout. Top, schematic representation of the asah2 locus (black boxes, exons; ATG, start codon) and two sgRNA target sites (orange boxes). Bottom left, DNA sequences of WT and asah2 KO. The red horizontal line denotes the 4 bp deletion. Bottom right, the mutation was predicted to result in loss of the C-terminal domain of the Asah2 protein. Blue, catalytic domain; orange, Ig-like domain; white, other regions; grey, asah2 KO N. furzeri- specific region. h , Expression of Asah2 in the intestine of short-lived N. furzeri analysed by Western blotting. i, j , asah2 KO extends lifespan ( i ) and improves locomotor activity ( j ). In i , survival curves of male WT (blue) and asah2 KO (orange) fish are shown on the left; the corresponding statistical results, mean lifespan and maximum lifespan are shown on the right. Black dots indicate censored individuals. Graphs in j show exploratory behaviour in male WT (blue) and asah2 KO (orange) fish. The y-axis indicates the average velocity. The log-rank test, fixed-time survival test, and unpaired two-tailed t -test were used for i , and a Brown–Forsythe and Welch ANOVA followed by Dunnett’s T3 multiple-comparisons test were used for j . Bars and error bars represent the mean ± SD.
Tissue Mrna Expression Data, supplied by Human Protein Atlas, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


a , Schematic representation of ceramide hydrolysis by membrane-tethered Asah2. Cer, ceramide; Sph, sphingosine. Image was created with BioRender.com. b , Loss of Asah2 activity is associated with a longer lifespan. Protein domain architectures of Asah2 are shown. Blue box, catalytic domain; orange box, immunoglobulin (Ig)-like domain; white box, other regions; grey box, N. furzeri MZM-specific region; red vertical lines in human ASAH2, essential amino acid residues required for enzymatic activity. c, e , asah2 is specifically expressed in the intestine and increases with age. Expression levels of asah2 mRNA in various tissues ( c ) and in the intestine ( e ) of 2- and 4-month-old wild-type (WT) and asah2 knockout (KO) N. furzeri are shown. In c and e , mRNA levels were analysed by reverse transcription quantitative PCR (RT–qPCR) and RNA sequencing (RNA-seq), respectively. CPM, counts per million; FDR, false discovery rate. FDR values were derived from quasi-likelihood methods in edgeR. d , Asah2 protein localises to the apical /luminal side of intestinal epithelium in short-lived GRZ fish but is absent in long-lived MZM fish and asah2 KO fish. Representative images of intestinal sections immunostained with anti-Asah2 antibody (green) and 4′,6-diamidino-2-phenylindole (DAPI; blue) are shown. Scale bar, 200 μm. f , Pooled censoring-aware parental survival analysis showing that higher participant plasma ASAH2 z-score was associated with higher pooled parental hazard, consistent with lower parental longevity. The displayed p-value tests the overall ASAH2-parental hazard association in the stratified cubic B-spline Cox model. Primary statistical inference was based on the cluster-robust linear Cox model. g , CRISPR/Cas9-mediated asah2 knockout. Top, schematic representation of the asah2 locus (black boxes, exons; ATG, start codon) and two sgRNA target sites (orange boxes). Bottom left, DNA sequences of WT and asah2 KO. The red horizontal line denotes the 4 bp deletion. Bottom right, the mutation was predicted to result in loss of the C-terminal domain of the Asah2 protein. Blue, catalytic domain; orange, Ig-like domain; white, other regions; grey, asah2 KO N. furzeri- specific region. h , Expression of Asah2 in the intestine of short-lived N. furzeri analysed by Western blotting. i, j , asah2 KO extends lifespan ( i ) and improves locomotor activity ( j ). In i , survival curves of male WT (blue) and asah2 KO (orange) fish are shown on the left; the corresponding statistical results, mean lifespan and maximum lifespan are shown on the right. Black dots indicate censored individuals. Graphs in j show exploratory behaviour in male WT (blue) and asah2 KO (orange) fish. The y-axis indicates the average velocity. The log-rank test, fixed-time survival test, and unpaired two-tailed t -test were used for i , and a Brown–Forsythe and Welch ANOVA followed by Dunnett’s T3 multiple-comparisons test were used for j . Bars and error bars represent the mean ± SD.

Journal: bioRxiv

Article Title: Inhibition of the gut ceramidase Asah2 decelerates the vertebrate ageing rate

doi: 10.64898/2026.04.30.721799

Figure Lengend Snippet: a , Schematic representation of ceramide hydrolysis by membrane-tethered Asah2. Cer, ceramide; Sph, sphingosine. Image was created with BioRender.com. b , Loss of Asah2 activity is associated with a longer lifespan. Protein domain architectures of Asah2 are shown. Blue box, catalytic domain; orange box, immunoglobulin (Ig)-like domain; white box, other regions; grey box, N. furzeri MZM-specific region; red vertical lines in human ASAH2, essential amino acid residues required for enzymatic activity. c, e , asah2 is specifically expressed in the intestine and increases with age. Expression levels of asah2 mRNA in various tissues ( c ) and in the intestine ( e ) of 2- and 4-month-old wild-type (WT) and asah2 knockout (KO) N. furzeri are shown. In c and e , mRNA levels were analysed by reverse transcription quantitative PCR (RT–qPCR) and RNA sequencing (RNA-seq), respectively. CPM, counts per million; FDR, false discovery rate. FDR values were derived from quasi-likelihood methods in edgeR. d , Asah2 protein localises to the apical /luminal side of intestinal epithelium in short-lived GRZ fish but is absent in long-lived MZM fish and asah2 KO fish. Representative images of intestinal sections immunostained with anti-Asah2 antibody (green) and 4′,6-diamidino-2-phenylindole (DAPI; blue) are shown. Scale bar, 200 μm. f , Pooled censoring-aware parental survival analysis showing that higher participant plasma ASAH2 z-score was associated with higher pooled parental hazard, consistent with lower parental longevity. The displayed p-value tests the overall ASAH2-parental hazard association in the stratified cubic B-spline Cox model. Primary statistical inference was based on the cluster-robust linear Cox model. g , CRISPR/Cas9-mediated asah2 knockout. Top, schematic representation of the asah2 locus (black boxes, exons; ATG, start codon) and two sgRNA target sites (orange boxes). Bottom left, DNA sequences of WT and asah2 KO. The red horizontal line denotes the 4 bp deletion. Bottom right, the mutation was predicted to result in loss of the C-terminal domain of the Asah2 protein. Blue, catalytic domain; orange, Ig-like domain; white, other regions; grey, asah2 KO N. furzeri- specific region. h , Expression of Asah2 in the intestine of short-lived N. furzeri analysed by Western blotting. i, j , asah2 KO extends lifespan ( i ) and improves locomotor activity ( j ). In i , survival curves of male WT (blue) and asah2 KO (orange) fish are shown on the left; the corresponding statistical results, mean lifespan and maximum lifespan are shown on the right. Black dots indicate censored individuals. Graphs in j show exploratory behaviour in male WT (blue) and asah2 KO (orange) fish. The y-axis indicates the average velocity. The log-rank test, fixed-time survival test, and unpaired two-tailed t -test were used for i , and a Brown–Forsythe and Welch ANOVA followed by Dunnett’s T3 multiple-comparisons test were used for j . Bars and error bars represent the mean ± SD.

Article Snippet: Human tissue expression data were obtained from the Human Protein Atlas , .

Techniques: Membrane, Activity Assay, Expressing, Knock-Out, Reverse Transcription, Real-time Polymerase Chain Reaction, Quantitative RT-PCR, RNA Sequencing, Derivative Assay, Clinical Proteomics, CRISPR, Mutagenesis, Western Blot, Two Tailed Test

a , Asah2 expression increases with age in the human terminal ileum of the small intestine. Data were obtained from voyAGEr . CPM, counts per million. b , Sex-stratified pooled censoring-aware parental survival analysis of participant plasma ASAH2 z-score and pooled parental hazard in male and female participants. Displayed p-values denote the overall ASAH2-parental hazard association from stratified cubic B-spline Cox models. c, d , asah2 KO does not affect body size or body mass index ( c ) or reproductive capacity ( d ). Graphs in c show body weight, body length, and body mass index in WT (blue) and asah2 KO (orange) male fish. Animals measured at each time point were different individuals. In d , the graph shows the number of fertilized eggs in WT (blue) and asah2 KO (orange) fish. Bars and error bars ( c, d ) represent the mean ± SD. An unpaired two-tailed t -test was used in c , and a Brown–Forsythe and Welch ANOVA followed by Dunnett’s T3 multiple-comparisons test were used in d .

Journal: bioRxiv

Article Title: Inhibition of the gut ceramidase Asah2 decelerates the vertebrate ageing rate

doi: 10.64898/2026.04.30.721799

Figure Lengend Snippet: a , Asah2 expression increases with age in the human terminal ileum of the small intestine. Data were obtained from voyAGEr . CPM, counts per million. b , Sex-stratified pooled censoring-aware parental survival analysis of participant plasma ASAH2 z-score and pooled parental hazard in male and female participants. Displayed p-values denote the overall ASAH2-parental hazard association from stratified cubic B-spline Cox models. c, d , asah2 KO does not affect body size or body mass index ( c ) or reproductive capacity ( d ). Graphs in c show body weight, body length, and body mass index in WT (blue) and asah2 KO (orange) male fish. Animals measured at each time point were different individuals. In d , the graph shows the number of fertilized eggs in WT (blue) and asah2 KO (orange) fish. Bars and error bars ( c, d ) represent the mean ± SD. An unpaired two-tailed t -test was used in c , and a Brown–Forsythe and Welch ANOVA followed by Dunnett’s T3 multiple-comparisons test were used in d .

Article Snippet: Human tissue expression data were obtained from the Human Protein Atlas , .

Techniques: Expressing, Clinical Proteomics, Two Tailed Test